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Total Syntheses of Cystobactamids and Structural Confirmation of Cystobactamid 919-2.
Cheng, Bichu Müller, Rolf Trauner, Dirk
Cheng, Bichu
Müller, Rolf
Trauner, Dirk
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2017-08-30
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Abstract
The cystobactamids are a family of antibacterial natural products with unprecedented chemical scaffolds that are active against both Gram-positive and Gram-negative pathogens. Herein, we describe the first total synthesis of cystobactamid 919-2 from three fragments. Our convergent synthesis enabled both the confirmation of the correct structure and the determination of the absolute configuration of cystobactamid 919-2.
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Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12755-12759. doi: 10.1002/anie.201705387. Epub 2017 Aug 30.
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en
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1521-3773
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Attribution 4.0 International