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Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice.
Leist, Sarah R Pilzner, Carolin van den Brand, Judith M A Dengler, Leonie Kuiken, Thijs Balling, Rudi Kollmus, Heike
Leist, Sarah R
Pilzner, Carolin
van den Brand, Judith M A
Dengler, Leonie
Kuiken, Thijs
Balling, Rudi
Kollmus, Heike
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Abstract
Influenza A virus is a zoonotic pathogen that poses a major threat to human and animal health. The severe course of influenza infection is not only influenced by viral virulence factors but also by individual differences in the host response. To determine the extent to which the genetic background can modulate severity of an infection, we studied the host responses to influenza infections in the eight genetically highly diverse Collaborative Cross (CC) founder mouse strains.
Citation
Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice. 2016, 17 (1):143 BMC Genomics
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Journal
PubMed ID
PubMed Central ID
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Article
Language
en
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Series/Report no.
ISSN
1471-2164