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Statistical Significance of Local Alignments with Gaps

Vingron, Martin
; 
Waterman, Michael S.
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Issue Date
1995
Submitted date
2024-05-29
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Abstract
Recent results on the statistical significance of local alignment with gaps are presented. Parameters necessary for computation of the probability that an alignment achieves a certain score can be approximated by a computationally fast simulation. We present applications to database searching where there-sorting of the output bystatistical significance instead of score leads to improved ability to distinguish sequences homologous to the probe sequence from unrelated sequences.
Citation
Bioinformatics - from nucleic acids and proteins to cell metabolism, 75 - 84
Affiliation
GMD - German National Research Center for Information Technology Institute for Algorithms and Scientific Computing (SCAI) Schloß Birlinghoven, D-53754 St. Augustin, Germany and Departments of Mathematics and Molecular Biology University of Southern California Los Angeles, California 90089-1113, U.S.A.
Publisher
GBF Gesellschaft für Biotechnologische Forschung mbH, Braunschweig
Journal
Bioinformatics - from nucleic acids and proteins to cell metabolism, 1995
URI
http://hdl.handle.net/10033/623851
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Type
Book chapter
conference paper
Language
en
Description
Series/Report no.
GBF monographs ; Volume 18
ISSN
0930-4320
EISSN
ISBN
3527300724
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License
Attribution-NonCommercial-ShareAlike 4.0 International
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