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Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction.
Fang, Kechi Zhao, Hansheng Sun, Changyue Lam, Carolyn M C Chang, Suhua Zhang, Kunlin Panda, Gurudutta Godinho, Miguel Martins dos Santos, Vítor A P Wang, Jing
Fang, Kechi
Zhao, Hansheng
Sun, Changyue
Lam, Carolyn M C
Chang, Suhua
Zhang, Kunlin
Panda, Gurudutta
Godinho, Miguel
Martins dos Santos, Vítor A P
Wang, Jing
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Abstract
Burkholderia cenocepacia is a threatening nosocomial epidemic pathogen in patients with cystic fibrosis (CF) or a compromised immune system. Its high level of antibiotic resistance is an increasing concern in treatments against its infection. Strain B. cenocepacia J2315 is the most infectious isolate from CF patients. There is a strong demand to reconstruct a genome-scale metabolic network of B. cenocepacia J2315 to systematically analyze its metabolic capabilities and its virulence traits, and to search for potential clinical therapy targets.
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Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction. 2011, 5:83 BMC Syst Biol
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1752-0509
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Archived with thanks to BMC systems biology