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Algorithmic Representation of Large RNA Folding Landscapes

Grüner, Walter
; 
Giegerich, Robert
; 
Strothmann, Dirk
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Issue Date
1995
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2024-05-29
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Abstract
In evolutionary processes on the molecularlevel, neutral alterations play an important role [Kim83]. The primary sequence of a DNA or RNA moleculeis changed by errors introduced by the replication machinery at certain rates. Such a mutation does not necessarily affect the phenotype. The molecule’s contribution to the individual’s overall fitness is mediated by its function. For non-encoding RNA, the function in turn is determined by the 3D-structure of the molecule. A mutation in the primary sequence of such an RNA molecule that does notalter its structure is called neutral.
Citation
Bioinformatics - from nucleic acids and proteins to cell metabolism, 59 - 71
Affiliation
Institut für Molekulare Biotechnologie, Beutenbergstrasse 1, D-07708 Jena, Germany; Technische Fakultät, Univ. Bielefeld, Postfach 10 01 31, D-33501 Bielefeld, Germany
Publisher
GBF Gesellschaft für Biotechnologische Forschung mbH, Braunschweig
Journal
Bioinformatics - from nucleic acids and proteins to cell metabolism, 1995
URI
http://hdl.handle.net/10033/623850
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Book chapter
conference paper
Language
en
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Series/Report no.
GBF monographs ; Volume 18
ISSN
0930-4320
EISSN
ISBN
3527300724
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Attribution-NonCommercial-ShareAlike 4.0 International
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