Loading...
Six Heterocyclic Metabolites from the Myxobacterium Labilithrix luteola.
Mulwa, Lucky S Jansen, Rolf Praditya, Dimas F Mohr, Kathrin I Wink, Joachim
Mulwa, Lucky S
Jansen, Rolf
Praditya, Dimas F
Mohr, Kathrin I
Wink, Joachim
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2018-02-28
Submitted date
Files
Loading...
Open Access publication
Adobe PDF, 713.85 KB
Other Titles
Abstract
Two new secondary metabolites, labindole A [2-methyl-3-(2-nitroethyl)-3H-indole] (1) and labindole B [2-methyl-3-(2-nitrovinyl)-3H-indole] (2), were isolated from the myxobacteriumLabilithrixluteola(DSM 27648T). Additionally, four metabolites3,4,5and6already known from other sources were obtained. Their structures were elucidated from high resolution electrospray ionisation mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) spectroscopy data and their relative configuration was assigned based on nuclear Overhauser effect (NOE) and vicinal ¹H-NMR coupling data. The compounds where tested for biological activities; labindoles A (1) and B (2) exhibited significant activity against Hepatitis C Virus, 9H-carbazole (3), 3-chloro-9H-carbazole (4) and 4-hydroxymethyl-quinoline (5) showed antifungal activities. Moreover, compound3had weak to moderate antibacterial activities, while labindoles A (1) and B (2) were devoid of significant antifungal and antibacterial effects.
Citation
Six Heterocyclic Metabolites from the Myxobacterium Labilithrix luteola. 2018, 23 (3) Molecules
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
en
Description
Series/Report no.
ISSN
1420-3049