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Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.
Schulte-Schrepping, Jonas Reusch, Nico Paclik, Daniela Baßler, Kevin Schlickeiser, Stephan Zhang, Bowen Krämer, Benjamin Krammer, Tobias Brumhard, Sophia Bonaguro, Lorenzo
Schulte-Schrepping, Jonas
Reusch, Nico
Paclik, Daniela
Baßler, Kevin
Schlickeiser, Stephan
Zhang, Bowen
Krämer, Benjamin
Krammer, Tobias
Brumhard, Sophia
Bonaguro, Lorenzo
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2020-08-05
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Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DRhiCD11chi inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DRlo monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.
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Cell. 2020 Sep 17;182(6):1419-1440.e23. doi: 10.1016/j.cell.2020.08.001.
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en
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1097-4172
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publications of the research group bioinformatics in infection
research ([BRICS] BIFO)
publications of the department of RNA biology of bacterial infections([HIRI] RABI)
publications of the research group genomeanalytics (GMAK)
publications of the working group of computational biology for individualized medicine ([CiiM] BIIM)
publications of theresearch group Single Cell Analysis ([HIRI] SIGA)
publications of the department of RNA biology of bacterial infections([HIRI] RABI)
publications of the research group genomeanalytics (GMAK)
publications of the working group of computational biology for individualized medicine ([CiiM] BIIM)
publications of theresearch group Single Cell Analysis ([HIRI] SIGA)