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Ala-geninthiocin, a new broad spectrum thiopeptide antibiotic, produced by a marine Streptomyces sp. ICN19.
Iniyan, Appadurai Muthamil Sudarman, Enge Wink, Joachim Kannan, Rajaretinam Rajesh Vincent, Samuel Gnana Prakash
Iniyan, Appadurai Muthamil
Sudarman, Enge
Wink, Joachim
Kannan, Rajaretinam Rajesh
Vincent, Samuel Gnana Prakash
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2018-10-24
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Bioassay-guided screening of antibacterial compounds from the cultured marine Streptomyces sp. ICN19 provided Ala-geninthiocin (1), along with its known analogs geninthiocin (2) and Val-geninthiocin (3) and the indolocarbazole staurosporine (4). The structure of 1 was determined on the basis of 1D and 2D NMR spectra and ESI-HRMS. The absolute configurations of the amino acid residues were determined by enantioselective GC-MS analysis. Compound 1 exhibited potent activity against Gram-positive bacteria including Staphylococcus aureus, Bacillus subtilis, Mycobacterium smegmatis, and Micrococcus luteus, as well as cytotoxicity against A549 human lung carcinoma cells with an IC50 value of 6 nM
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0021-8820
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Attribution-NonCommercial-ShareAlike 3.0 United States