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Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S-Component of the Energy-Coupling Factor Transporter for Thiamine.
Monjas, Leticia Swier, Lotteke J Y M Setyawati, Inda Slotboom, Dirk J Hirsch, Anna K H
Monjas, Leticia
Swier, Lotteke J Y M
Setyawati, Inda
Slotboom, Dirk J
Hirsch, Anna K H
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2017-10-20
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Abstract
We applied dynamic combinatorial chemistry (DCC) to identify ligands of ThiT, the S-component of the energy-coupling factor (ECF) transporter for thiamine in Lactococcus lactis. We used a pre-equilibrated dynamic combinatorial library (DCL) and saturation-transfer difference (STD) NMR spectroscopy to identify ligands of ThiT. This is the first report in which DCC is used for fragment growing to an ill-defined pocket, and one of the first reports for its application with an integral membrane protein as target.
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Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S-Component of the Energy-Coupling Factor Transporter for Thiamine. 2017, 12 (20):1693-1696 ChemMedChem
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en
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1860-7187