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Maturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity.
Bankwitz, Dorothea Doepke, Mandy Hueging, Kathrin Weller, Romy Bruening, Janina Behrendt, Patrick Lee, Ji-Young Vondran, Florian W R Manns, Michael P Bartenschlager, Ralf
Bankwitz, Dorothea
Doepke, Mandy
Hueging, Kathrin
Weller, Romy
Bruening, Janina
Behrendt, Patrick
Lee, Ji-Young
Vondran, Florian W R
Manns, Michael P
Bartenschlager, Ralf
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Issue Date
2017-04-22
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Abstract
Hepatitis C virus (HCV) evades humoral immunity and establishes chronic infections. Virus particles circulate in complex with lipoproteins facilitating antibody escape. Apolipoprotein E (ApoE) is essential for intracellular HCV assembly and for HCV cell entry. We aimed to explore if ApoE released from non-infected cells interacts with and modulates secreted HCV particles.
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Maturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity. 2017 J. Hepatol.
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en
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1600-0641