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Biological activity of volatiles from marine and terrestrial bacteria.

Schulz, Stefan
; 
Dickschat, Jeroen S
; 
Kunze, Brigitte
; 
Wagner-Döbler, Irene
; 
Diestel, Randi
; 
Sasse, Florenz
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2010
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Abstract
The antiproliferative activity of 52 volatile compounds released from bacteria was investigated in agar diffusion assays against medically important microorganisms and mouse fibroblasts. Furthermore, the activity of these compounds to interfere with the quorum-sensing-systems was tested with two different reporter strains. While some of the compounds specific to certain bacteria showed some activity in the antiproliferative assay, the compounds common to many bacteria were mostly inactive. In contrast, some of these compounds were active in the quorum-sensing-tests. γ-Lactones showed a broad reactivity, while pyrazines seem to have only low intrinsic activity. A general discussion on the ecological importance of these findings is given.
Citation
Biological activity of volatiles from marine and terrestrial bacteria. 2010, 8 (12):2976-87 Mar Drugs
Affiliation
Institute of Organic Chemistry, University of Braunschweig-Institute of Technology, Hagenring 30, Braunschweig, Germany. Stefan.Schulz@tu-bs.de
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Marine drugs
URI
http://hdl.handle.net/10033/134750
DOI
10.3390/md8122976
PubMed ID
21339960
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Article
Language
en
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1660-3397
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publications of the research group microbial communication (KOM)