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NS Segment of a 1918 Influenza A Virus-Descendent Enhances Replication of H1N1pdm09 and Virus-Induced Cellular Immune Response in Mammalian and Avian Systems.
Petersen, Henning Mostafa, Ahmed Tantawy, Mohamed A Iqbal, Azeem A Hoffmann, Donata Tallam, Aravind Selvakumar, Balachandar Pessler, Frank Beer, Martin Rautenschlein, Silke
Petersen, Henning
Mostafa, Ahmed
Tantawy, Mohamed A
Iqbal, Azeem A
Hoffmann, Donata
Tallam, Aravind
Selvakumar, Balachandar
Pessler, Frank
Beer, Martin
Rautenschlein, Silke
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2018-01-01
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Adobe PDF, 429.51 KB
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supplemental material
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Abstract
The 2009 pandemic influenza A virus (IAV) H1N1 strain (H1N1pdm09) has widely spread and is circulating in humans and swine together with other human and avian IAVs. This fact raises the concern that reassortment between H1N1pdm09 and co-circulating viruses might lead to an increase of H1N1pdm09 pathogenicity in different susceptible host species. Herein, we explored the potential of different NS segments to enhance the replication dynamics, pathogenicity and host range of H1N1pdm09 strain A/Giessen/06/09 (Gi-wt). The NS segments were derived from (i) human H1N1- and H3N2 IAVs, (ii) highly pathogenic- (H5- or H7-subtypes) or (iii) low pathogenic avian influenza viruses (H7- or H9-subtypes). A significant increase of growth kinetics in A549 (human lung epithelia) and NPTr (porcine tracheal epithelia) cells was only noticed
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1664-302X
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Attribution-NonCommercial-ShareAlike 3.0 United States