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The myxobacterial metabolite Soraphen A inhibits HIV-1 by reducing virus production and altering virion composition.

Fleta-Soriano, Eric
; 
Smutná, Katarína
; 
Martinez, Javier P
; 
Lorca Oró, Cristina
; 
Sadiq, S Kashif
; 
Mirambeau, Gilles
; 
Lopez-Iglesias, Carmen
; 
Bosch, Marta
; 
Pol, Albert
; ... show 2 more
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Issue Date
2017-05-22
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Abstract
Soraphen A is a myxobacterial metabolite that blocks the acetyl-CoA carboxylase of the host, and was previously identified as a novel HIV inhibitor. Here we report that Soraphen A acts by reducing virus production and altering the gp120 virion content, impacting entry capacity and infectivity. These effects are partially reversed by addition of palmitic acid, suggesting inhibition of HIV Env palmitoylation as one of the mechanisms of antiviral action.
Citation
The myxobacterial metabolite Soraphen A inhibits HIV-1 by reducing virus production and altering virion composition. 2017 Antimicrob. Agents Chemother.
Affiliation
Helmholtz Centre of infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
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Journal
Antimicrobial agents and chemotherapy
URI
http://hdl.handle.net/10033/620943
DOI
10.1128/AAC.00739-17
PubMed ID
28533249
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Article
Language
en
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1098-6596
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Publications of the research group Chemical Biology (CBIO)