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Computer Simulation of Multi-Color Brainbow Staining and Clonal Evolution of B Cells in Germinal Centers.

; 
Binder, Sebastian C
; 
Mesin, Luka
; 
Victora, Gabriel D
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2018-01-01
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Meyer-Hermann et al.pdf
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Abstract
Clonal evolution of B cells in germinal centers (GCs) is central to affinity maturation of antibodies in response to pathogens. Permanent or tamoxifen-induced multi-color recombination of B cells based on the brainbow allele allows monitoring the degree of color dominance in the course of the GC reaction. Here, we use computer simulations of GC reactions in order to replicate the evolution of color dominance
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Affiliation
BRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.
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URI
http://hdl.handle.net/10033/621534
DOI
10.3389/fimmu.2018.02020
PubMed ID
30319600
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ISSN
1664-3224
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Attribution-NonCommercial-ShareAlike 3.0 United States
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publications of the research group system immunology ([BRICS]SIMM)