Loading...
Redispersible Spray-Dried Powder Containing Nanoencapsulated Curcumin: the Drying Process Does Not Affect Neuroprotection In vitro.
de Andrade, Diego Fontana Vukosavljevic, Branko Hoppe, Juliana Bender Pohlmann, Adriana Raffin Guterres, Sílvia Stanisçuaski Windbergs, Maike Külkamp-Guerreiro, Irene Salbego, Christianne Gazzana Beck, Ruy Carlos Ruver
de Andrade, Diego Fontana
Vukosavljevic, Branko
Hoppe, Juliana Bender
Pohlmann, Adriana Raffin
Guterres, Sílvia Stanisçuaski
Windbergs, Maike
Külkamp-Guerreiro, Irene
Salbego, Christianne Gazzana
Beck, Ruy Carlos Ruver
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2019-08-12
Submitted date
Files
Loading...
De Andrade et al.pdf
Adobe PDF, 817.68 KB
Other Titles
Abstract
A redispersible spray-dried formulation containing curcumin-loaded, lipid-core nanocapsules (LNC-C) was developed for oral administration. The neuroprotective activity of curcumin after the spray-drying process was evaluated in vitro. The spray-dried powder (SD-LNC-C) was produced using a drying adjuvant composed of a blend of maltodextrin and L-leucine (90:10 w/w). Acceptable process yield (~ 70%) and drug content (6.5 ± 0.2 mg g-1) were obtained. SD-LNC-C was formed by smooth, spherical-shaped particles, and confocal Raman analysis indicated the distribution of the LNC-C on the surface of the leucine/maltodextrin agglomerates. The surface of the agglomerates was formed by a combination of LNC-C and adjuvants, and laser diffraction showed that SD-LNC-C had adequate aqueous redispersion, with no loss of controlled drug release behaviour of LNC-C. The in vitro curcumin activity against the lipopolysaccharide (LPS)-induced proinflammatory response in organotypic hippocampal slice cultures was evaluated. Both formulations (LNC-C and SD-LNC-C) reduced TNF-α to similar levels. Therefore, neuroprotection of curcumin in vitro may be improved by nanoencapsulation followed by spray-drying, with no loss of this superior performance. Hence, the redispersible spray-dried powder proposed here represents a suitable approach for the development of innovative nanomedicines containing curcumin for the prevention/treatment of neurodegenerative diseases.
Citation
AAPS PharmSciTech. 2019 Aug 12;20(7):283. doi: 10.1208/s12249-019-1501-1.
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
en
Description
Series/Report no.
ISSN
EISSN
1530-9932
ISBN
ISMN
Gov't Doc #
Sponsors
License
Attribution 4.0 International