Loading...
Atlas der SARS-CoV-2-RNA-Protein-Interaktionen in infizierten Zellen
Schmidt, Nora Munschauer, Mathias
Schmidt, Nora
Munschauer, Mathias
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2021-06-26
Submitted date
Files
Loading...
Open Access publication
Adobe PDF, 703.25 KB
Other Titles
Abstract
Using RNA antisense purification and mass spectrometry, we identified more than 100 human proteins that directly and specifically bind SARS-CoV-2 RNA in infected cells. To gain insights into the functions of selected RNA interactors, we applied genetic perturbation and pharmacological inhibition experiments, and mapped the contact sites on the viral RNA. This led to the identification of host dependency factors and defense strategies, which can guide the design of novel therapeutics against SARS-CoV-2.
Citation
Biospektrum 27, 376–379 (2021). https://doi.org/10.1007/s12268-021-1587-3.
Publisher
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Review
Language
de
Description
Series/Report no.
ISSN
0947-0867
EISSN
ISBN
ISMN
Gov't Doc #
Sponsors
License
Attribution 4.0 International