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Hypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a pantropical insecticide-producing endophyte.

Bills, Gerald F
; 
González-Menéndez, Victor
; 
Martín, Jesús
; 
Platas, Gonzalo
; 
Fournier, Jacques
; 
Peršoh, Derek
; 
Stadler, Marc
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2012
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Abstract
Nodulisporic acids (NAs) are indole diterpene fungal metabolites exhibiting potent systemic efficacy against blood-feeding arthropods, e.g., bedbugs, fleas and ticks, via binding to arthropod specific glutamate-gated chloride channels. Intensive medicinal chemistry efforts employing a nodulisporic acid A template have led to the development of N-tert-butyl nodulisporamide as a product candidate for a once monthly treatment of fleas and ticks on companion animals. The source of the NAs is a monophyletic lineage of asexual endophytic fungal strains that is widely distributed in the tropics, tentatively identified as a Nodulisporium species and hypothesized to be the asexual state of a Hypoxylon species.
Citation
Hypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a pantropical insecticide-producing endophyte. 2012, 7 (10):e46687 PLoS ONE
Affiliation
Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Parque Tecnológico de Ciencias de la Salud, Armilla, Granada, Spain. gerald.bills@medinaandalucia.es
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PloS one
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http://hdl.handle.net/10033/265912
DOI
10.1371/journal.pone.0046687
PubMed ID
23056404
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en
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1932-6203
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publications of the research group of microbial drugs (MWIS)