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The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2.
Krause-Gruszczynska, Malgorzata Boehm, Manja Rohde, Manfred Tegtmeyer, Nicole Takahashi, Seiichiro Buday, Laszlo Oyarzabal, Omar A Backert, Steffen
Krause-Gruszczynska, Malgorzata
Boehm, Manja
Rohde, Manfred
Tegtmeyer, Nicole
Takahashi, Seiichiro
Buday, Laszlo
Oyarzabal, Omar A
Backert, Steffen
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Abstract
Host cell invasion by the foodborne pathogen Campylobacter jejuni is considered as one of the primary reasons of gut tissue damage, however, mechanisms and key factors involved in this process are widely unclear. It was reported that small Rho GTPases, including Cdc42, are activated and play a role during invasion, but the involved signaling cascades remained unknown. Here we utilised knockout cell lines derived from fibronectin-/-, integrin-beta1-/-, focal adhesion kinase (FAK)-/- and Src/Yes/Fyn-/- deficient mice, and wild-type control cells, to investigate C. jejuni-induced mechanisms leading to Cdc42 activation and bacterial uptake.
Citation
The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2. 2011, 9:32 Cell Commun. Signal
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PubMed Central ID
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Article
Language
en
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Series/Report no.
ISSN
1478-811X