Loading...
Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.
Tomić, Adriana Varanasi, Pavankumar R Golemac, Mijo Malić, Suzana Borst, Eva M Mischak-Weissinger, Eva Guzmán, Carlos A Krmpotić, Astrid Jonjić, Stipan
Tomić, Adriana
Varanasi, Pavankumar R
Golemac, Mijo
Malić, Suzana
Borst, Eva M
Mischak-Weissinger, Eva
Guzmán, Carlos A
Krmpotić, Astrid
Jonjić, Stipan
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2016-12
Submitted date
Files
Loading...
Open Access publication
Adobe PDF, 6.09 MB
Other Titles
Abstract
Development of an effective vaccine against human cytomegalovirus (HCMV) is a need of utmost medical importance. Generally, it is believed that a live attenuated vaccine would best provide protective immunity against this tenacious pathogen. Here, we propose a strategy for an HCMV vaccine that aims at the simultaneous activation of innate and adaptive immune responses. An HCMV strain expressing the host ligand ULBP2 for the NKG2D receptor was found to be susceptible to control by natural killer (NK) cells, and preserved the ability to stimulate HCMV-specific T cells. Infection with the ULBP2-expressing HCMV strain caused diminished cell surface levels of MHC class I molecules. While expression of the NKG2D ligand increased the cytolytic activity of NK cells, NKG2D engagement in CD8+ T cells provided co-stimulation and compensated for lower MHC class I expression. Altogether, our data indicate that triggering of both arms of the immune system is a promising approach applicable to the generation of a live attenuated HCMV vaccine.
Citation
Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand. 2016, 12 (12):e1006015 PLoS Pathog.
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
en
Description
Series/Report no.
ISSN
1553-7374