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TCR-triggered extracellular superoxide production is not required for T-cell activation.

Belikov, Aleksey V
; 
Schraven, Burkhart
; 
Simeoni, Luca
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2014
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Abstract
In the last decade, reactive oxygen species (ROS) production has been shown to occur upon T-cell receptor (TCR) stimulation and to affect TCR-mediated signalling. However, the exact reactive species that are produced, how ROS are generated and their requirement for T-cell activation, proliferation or cytokine production remain unclear, especially in the case of primary human T cells. Moreover, several groups have questioned that ROS are produced upon TCR stimulation.
Citation
TCR-triggered extracellular superoxide production is not required for T-cell activation. 2014, 12:50 Cell Commun. Signal
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Cell communication and signaling : CCS
URI
http://hdl.handle.net/10033/332622
DOI
10.1186/s12964-014-0050-1
PubMed ID
25081034
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Article
Language
en
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1478-811X
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Archived with thanks to Cell communication and signaling : CCS
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publications of the research group of immune control (IMMK)