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CHARACTERISTICS AND APPLICATION OF A CONTINUOUS GLUCOSE REGISTRATION DEVICE USING THE MICRODIALYSIS TECHNIQUE
Keck, F. S. Kerner, W. Meyerhoff, C. Zier, Holger
Keck, F. S.
Kerner, W.
Meyerhoff, C.
Zier, Holger
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Issue Date
1992
Submitted date
2024-05-08
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Abstract
A device for continuous registration of dissolved glucose was obtained by combining the microdialysis technique with the measuring flow chamber of a glucose monitor using the glucose oxidase method for the determination of glucose concentration. In in vitro experiments it was demonstrated that the glucose signal registered by this device is inversely related to the flow rate, which, in turn, is inversely related to the response time of the device. The glucose signal increased linearly with the area of the microdialysis working membrane and with the glucose concentrations of the standard solutions. The influences of temperature changes of the glucose standard solutions upon the glucose signal were determined by 1.32%/degc. In in vivo experiments, a needle type microdialysis probe was implanted subcutaneously in rats, whose blood glucose concentration was varied between 40 and 122 mg/dl. Blood glucose concentration was followed closely by the glucose signal obtained from the subcutaneous probe (r = 0.94) over a 240 min registration time period.
Citation
Biosensors : fundamentals, technologies and applications, 375 - 378
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Book chapter
conference paper
conference paper
Language
en
Description
Series/Report no.
GBF monographs ; Volume 17
ISSN
0930-4320
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ISBN
1560812206
3527284370
3527284370
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Attribution-NonCommercial-ShareAlike 4.0 International