Loading...
Yersinia Type III Secretion System Master Regulator LcrF.
Schwiesow, Leah Lam, Hanh Dersch, Petra Auerbuch, Victoria
Schwiesow, Leah
Lam, Hanh
Dersch, Petra
Auerbuch, Victoria
Files
Loading...
allowed publisher's PDF
Adobe PDF, 1.65 MB
Other Titles
Abstract
Many Gram-negative pathogens express a type III secretion (T3SS) system to enable growth and survival within a host. The three human-pathogenic Yersinia species, Y. pestis, Y. pseudotuberculosis, and Y. enterocolitica, encode the Ysc T3SS, whose expression is controlled by an AraC-like master regulator called LcrF. In this review, we discuss LcrF structure and function as well as the environmental cues and pathways known to regulate LcrF expression. Similarities and differences in binding motifs and modes of action between LcrF and the Pseudomonas aeruginosa homolog ExsA are summarized. In addition, we present a new bioinformatics analysis that identifies putative LcrF binding sites within Yersinia target gene promoters.
Citation
Yersinia Type III Secretion System Master Regulator LcrF. 2015, 198 (4):604-14 J. Bacteriol.
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
en
Description
Series/Report no.
ISSN
1098-5530