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DIGGER: exploring the functional role of alternative splicing in protein interactions.
Louadi, Zakaria Yuan, Kevin Gress, Alexander Tsoy, Olga Kalinina, Olga V Baumbach, Jan Kacprowski, Tim List, Markus
Louadi, Zakaria
Yuan, Kevin
Gress, Alexander
Tsoy, Olga
Kalinina, Olga V
Baumbach, Jan
Kacprowski, Tim
List, Markus
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2020-09-25
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Abstract
Alternative splicing plays a major role in regulating the functional repertoire of the proteome. However, isoform-specific effects to protein-protein interactions (PPIs) are usually overlooked, making it impossible to judge the functional role of individual exons on a systems biology level. We overcome this barrier by integrating protein-protein interactions, domain-domain interactions and residue-level interactions information to lift exon expression analysis to a network level. Our user-friendly database DIGGER is available at https://exbio.wzw.tum.de/digger and allows users to seamlessly switch between isoform and exon-centric views of the interactome and to extract sub-networks of relevant isoforms, making it an essential resource for studying mechanistic consequences of alternative splicing.
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Nucleic Acids Res. 2020 Sep 25:gkaa768. doi: 10.1093/nar/gkaa768. Epub ahead of print.
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en
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1362-4962
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Attribution-NonCommercial-ShareAlike 4.0 International