Loading...
Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium.
Wang, Z Friedrich, C Hagemann, S C Korte, W H Goharani, N Cording, S Eberl, G Sparwasser, Tim Lochner, M
Wang, Z
Friedrich, C
Hagemann, S C
Korte, W H
Goharani, N
Cording, S
Eberl, G
Sparwasser, Tim
Lochner, M
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2014-11
Submitted date
Files
Loading...
original manuscript
Adobe PDF, 1.16 MB
Other Titles
Abstract
Intestinal infection with the mouse pathogen Citrobacter rodentium induces a strong local Th17 response in the colon. Although this inflammatory immune response helps to clear the pathogen, it also induces inflammation-associated pathology in the gut and thus, has to be tightly controlled. In this project, we therefore studied the impact of Foxp3(+) regulatory T cells (Treg) on the infectious and inflammatory processes elicited by the bacterial pathogen C. rodentium. Surprisingly, we found that depletion of Treg by diphtheria toxin in the Foxp3(DTR) (DEREG) mouse model resulted in impaired bacterial clearance in the colon, exacerbated body weight loss, and increased systemic dissemination of bacteria. Consistent with the enhanced susceptibility to infection, we found that the colonic Th17-associated T-cell response was impaired in Treg-depleted mice, suggesting that the presence of Treg is crucial for the establishment of a functional Th17 response after the infection in the gut. As a consequence of the impaired Th17 response, we also observed less inflammation-associated pathology in the colons of Treg-depleted mice. Interestingly, anti-interleukin (IL)-2 treatment of infected Treg-depleted mice restored Th17 induction, indicating that Treg support the induction of a protective Th17 response during intestinal bacterial infection by consumption of local IL-2.
Citation
Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium. 2014, 7 (6):1290-301 Mucosal Immunol
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
en
Description
Series/Report no.
ISSN
1935-3456