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Peripheral T-cell lymphoma cell line T8ML-1 highlights conspicuous targeting of PVRL2 by t(14;19)(q11.2;q13.3).

Ehrentraut, Stefan
; 
Nagel, Stefan
; ; 
Dirks, Wilhelm G
; 
Quentmeier, Hilmar
; 
Kaufmann, Maren
; 
Meyer, Corinna
; 
Zaborski, Margarete
; ; 
Fujiwara, Hiroshi
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2017-01-01
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Abstract
Focal amplifications and chromosome translocations involving the long arm of chromosome 19 (19q13.3) are recurrent in T-cell lymphoma, where neighboring BCL3 and PVRL2 are competing target genes. Here we present the oncogenomic characterization of a peripheral T-cell lymphoma (PTCL) cell line T8ML-1 to reveal t(14;19)(q11.2;q13.3) juxtaposing TRA@ and PVRL2. Parallel mRNA and protein expression data for the 19q13.3 region of interest pinpointed PVRL2 as the sole conspicuous target therein. Collectively, our findings endorse T8ML-1 as the first proven cell line model for t(14;19)/PTCL.
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Affiliation
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
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http://hdl.handle.net/10033/621450
DOI
10.3324/haematol.2017.168203
PubMed ID
28659334
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1592-8721
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Attribution-NonCommercial-ShareAlike 3.0 United States
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publications of the research group genomeanalytics (GMAK)