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E-N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells.
Straub, Beate K Rickelt, Steffen Zimbelmann, Ralf Grund, Christine Kuhn, Caecilia Iken, Marcus Ott, Michael Schirmacher, Peter Franke, Werner W
Straub, Beate K
Rickelt, Steffen
Zimbelmann, Ralf
Grund, Christine
Kuhn, Caecilia
Iken, Marcus
Ott, Michael
Schirmacher, Peter
Franke, Werner W
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2011-11-28
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Abstract
Intercellular junctions play a pivotal role in tissue development and function and also in tumorigenesis. In epithelial cells, decrease or loss of E-cadherin, the hallmark molecule of adherens junctions (AJs), and increase of N-cadherin are widely thought to promote carcinoma progression and metastasis. In this paper, we show that this "cadherin switch" hypothesis does not hold for diverse endoderm-derived cells and cells of tumors derived from them. We show that the cadherins in a major portion of AJs in these cells can be chemically cross-linked in E-N heterodimers. We also show that cells possessing E-N heterodimer AJs can form semistable hemihomotypic AJs with purely N-cadherin-based AJs of mesenchymally derived cells, including stroma cells. We conclude that these heterodimers are the major AJ constituents of several endoderm-derived tissues and tumors and that the prevailing concept of antagonistic roles of these two cadherins in developmental and tumor biology has to be reconsidered.
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E-N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells. 2011, 195 (5):873-87 J. Cell Biol.
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en
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1540-8140
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Archived with thanks to The Journal of cell biology