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The vinculin-DeltaIn20/21 mouse: characteristics of a constitutive, actin-binding deficient splice variant of vinculin.
Marg, Susanna Winkler, Ulrike Sestu, Marcello Himmel, Mirko Schönherr, Madeleine Bär, Janina Mann, Amrit Moser, Markus Mierke, Claudia T Rottner, Klemens
Marg, Susanna
Winkler, Ulrike
Sestu, Marcello
Himmel, Mirko
Schönherr, Madeleine
Bär, Janina
Mann, Amrit
Moser, Markus
Mierke, Claudia T
Rottner, Klemens
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Abstract
The cytoskeletal adaptor protein vinculin plays a fundamental role in cell contact regulation and affects central aspects of cell motility, which are essential to both embryonal development and tissue homeostasis. Functional regulation of this evolutionarily conserved and ubiquitously expressed protein is dominated by a high-affinity, autoinhibitory head-to-tail interaction that spatially restricts ligand interactions to cell adhesion sites and, furthermore, limits the residency time of vinculin at these sites. To date, no mutants of the vinculin protein have been characterized in animal models.
Citation
The vinculin-DeltaIn20/21 mouse: characteristics of a constitutive, actin-binding deficient splice variant of vinculin. 2010, 5 (7):e11530 PLoS ONE
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en
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1932-6203