Department of Epidemiologie (EPID)
http://hdl.handle.net/10033/211390
2024-03-29T06:28:15ZDiscovery and validation of a personalized risk predictor for incident tuberculosis in low transmission settings.
http://hdl.handle.net/10033/623239
Discovery and validation of a personalized risk predictor for incident tuberculosis in low transmission settings.
Gupta, Rishi K; Calderwood, Claire J; Yavlinsky, Alexei; Krutikov, Maria; Quartagno, Matteo; Aichelburg, Maximilian C; Altet, Neus; Diel, Roland; Dobler, Claudia C; Dominguez, Jose; Doyle, Joseph S; Erkens, Connie; Geis, Steffen; Haldar, Pranabashis; Hauri, Anja M; Hermansen, Thomas; Johnston, James C; Lange, Christoph; Lange, Berit; van Leth, Frank; Muñoz, Laura; Roder, Christine; Romanowski, Kamila; Roth, David; Sester, Martina; Sloot, Rosa; Sotgiu, Giovanni; Woltmann, Gerrit; Yoshiyama, Takashi; Zellweger, Jean-Pierre; Zenner, Dominik; Aldridge, Robert W; Copas, Andrew; Rangaka, Molebogeng X; Lipman, Marc; Noursadeghi, Mahdad; Abubakar, Ibrahim
2020-10-19T00:00:00ZA Probabilistic Cohort-Component Model for Population Forecasting – The Case of Germany
http://hdl.handle.net/10033/623225
A Probabilistic Cohort-Component Model for Population Forecasting – The Case of Germany
Vanella, Patrizio; Deschermeier, Philipp
2020-01-02T00:00:00ZAn Overview of Population Projections—Methodological Concepts, International Data Availability, and Use Cases
http://hdl.handle.net/10033/623209
An Overview of Population Projections—Methodological Concepts, International Data Availability, and Use Cases
Vanella, Patrizio; Deschermeier, Philipp; Wilke, Christina B.
Population projections serve various actors at subnational, national, and international
levels as a quantitative basis for political and economic decision-making. Usually, the users are
no experts in statistics or forecasting and therefore lack the methodological and demographic
background to completely understand methods and limitations behind the projections they use to
inform further analysis. Our contribution primarily targets that readership. Therefore, we give
a brief overview of di erent approaches to population projection and discuss their respective
advantages and disadvantages, alongside practical problems in population data and forecasting.
Fundamental di erences between deterministic and stochastic approaches are discussed, with special
emphasis on the advantages of stochastic approaches. Next to selected projection data available to the
public, we show central areas of application of population projections, with an emphasis on Germany
2020-09-02T00:00:00ZThe assessment of childhood maltreatment and its associations with affective symptoms in adulthood: Results of the German National Cohort (NAKO).
http://hdl.handle.net/10033/623173
The assessment of childhood maltreatment and its associations with affective symptoms in adulthood: Results of the German National Cohort (NAKO).
Klinger-König, Johanna; Streit, Fabian; Erhardt, Angelika; Kleineidam, Luca; Schmiedek, Florian; Schmidt, Börge; Investigators, Nako; Wagner, Michael; Deckert, Jürgen; Rietschel, Marcella; Berger, Klaus; Grabe, Hans J
Overall, 21,131 participants (27.5%) reported at least one type of childhood maltreatment; 14,017 participants (18.3%) reported exactly one type and 250 participants (0.3%) reported all five types of childhood maltreatment. Small differences regarding age (mean absolute deviation around the mean (MAD)=0.47), sex (MAD = 0.07) and education (MAD = 0.82) were observed. The severity of childhood maltreatment was associated with more severe symptoms of depression (β = 0.23), anxiety (β = 0.21) and perceived stress (β = 0.23) in adulthood, validated particularly for emotional abuse and emotional neglect.
Objectives: Childhood maltreatment affects 20-30% of the German population and is an important risk factor for physical and mental diseases in adult life. This study reports first results of the distribution of childhood maltreatment in the population-based mega cohort German National Cohort (NAKO) and estimates associations with affective symptoms in adulthood.
Methods: The Childhood Trauma Screener (CTS), a short version of the Childhood Trauma Questionnaire, was used in 83,995 adults (age: 20-72 years; 47.3% men) of NAKO. The five-item CTS assesses the severity of three types of childhood abuse and two types of childhood neglect.
Results: Overall, 21,131 participants (27.5%) reported at least one type of childhood maltreatment; 14,017 participants (18.3%) reported exactly one type and 250 participants (0.3%) reported all five types of childhood maltreatment. Small differences regarding age (mean absolute deviation around the mean (MAD)=0.47), sex (MAD = 0.07) and education (MAD = 0.82) were observed. The severity of childhood maltreatment was associated with more severe symptoms of depression (β = 0.23), anxiety (β = 0.21) and perceived stress (β = 0.23) in adulthood, validated particularly for emotional abuse and emotional neglect.
Conclusions: The distribution of childhood maltreatment in NAKO is similar to previous reports. Additionally, our results suggest differential associations with psychopathological symptoms for the five types of childhood maltreatment.
2022-03-18T00:00:00Z