http://hdl.handle.net/10033/196534 Tue, 19 May 2026 16:20:46 GMT 2026-05-19T16:20:46Z http://hdl.handle.net/10033/621840 Hepatocyte transplantation, a step forward? Ott, Michael; Castell, Jose V Editorial Sat, 01 Jun 2019 00:00:00 GMT http://hdl.handle.net/10033/621840 2019-06-01T00:00:00Z http://hdl.handle.net/10033/621336 Homologous recombination mediates stable Fah gene integration and phenotypic correction in tyrosinaemia mouse-model. Junge, Norman; Yuan, Qinggong; Vu, Thu Huong; Krooss, Simon; Bednarski, Christien; Balakrishnan, Asha; Cathomen, Toni; Manns, Michael P; Baumann, Ulrich; Sharma, Amar Deep; Ott, Michael To stably correct tyrosinaemia in proliferating livers of fumarylacetoacetate-hydrolase knockout (Fah-/-)mice by homologous-recombination-mediated targeted addition of theFahgene. Tue, 27 Feb 2018 00:00:00 GMT http://hdl.handle.net/10033/621336 2018-02-27T00:00:00Z http://hdl.handle.net/10033/619994 MicroRNA-125b-5p mimic inhibits acute liver failure. Yang, Dakai; Yuan, Qinggong; Balakrishnan, Asha; Bantel, Heike; Klusmann, Jan-Henning; Manns, Michael P; Ott, Michael; Cantz, Tobias; Sharma, Amar Deep The lack of broad-spectrum anti-acute liver failure (ALF) therapeutic agents contributes to ALF-related mortality. MicroRNAs (miRNAs) are suggested to be potent serum biomarkers for ALF, but their functional and therapeutic relevance in ALF are unclear. Here we show an unbiased approach, using two complementary miRNA screens, to identify miRNAs that can attenuate ALF. We identify miR-125b-5p as a regulator of cell death that attenuates paracetamol-induced and FAS-induced toxicity in mouse and human hepatocytes. Importantly, administration of miR-125b-5p mimic in mouse liver prevents injury and improves survival in models of ALF. Functional studies show that miR-125b-5p ameliorates ALF by directly regulating kelch-like ECH-associated protein 1, in turn elevating expression of nuclear factor-E2-related factor 2, a known regulator in ALF. Collectively, our findings establish miR-125b-5p as an important regulator of paracetamol-induced and FAS-induced cell death. Thus, miR-125b-5p mimic may serve as a broad-spectrum therapeutic attenuator of cell death during ALF. Fri, 01 Jan 2016 00:00:00 GMT http://hdl.handle.net/10033/619994 2016-01-01T00:00:00Z http://hdl.handle.net/10033/596925 Determinants of tetanus, pneumococcal and influenza vaccination in the elderly: a representative cross-sectional study on knowledge, attitude and practice (KAP). Klett-Tammen, Carolina J; Krause, Gerard; Seefeld, Linda; Ott, Jördis J Severity and incidence of vaccine-preventable infections with influenza viruses, s. pneumoniae and c. tetani increase with age. Furthermore, vaccine coverage in the elderly is often insufficient. The aim of this study is to identify socio-economic and knowledge-, attitude- and practice- (KAP)-related determinants of vaccination against influenza, pneumococcal disease and tetanus in the older German population. Fri, 01 Jan 2016 00:00:00 GMT http://hdl.handle.net/10033/596925 2016-01-01T00:00:00Z