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dc.contributor.authorItzek, Andreas
dc.contributor.authorGillen, Christine M
dc.contributor.authorFulde, Marcus
dc.contributor.authorFriedrichs, Claudia
dc.contributor.authorRodloff, Arne C
dc.contributor.authorChhatwal, Gursharan S
dc.contributor.authorNitsche-Schmitz, Daniel Patric
dc.date.accessioned2010-12-03T15:41:05Z
dc.date.available2010-12-03T15:41:05Z
dc.date.issued2010
dc.identifier.citationContribution of plasminogen activation towards the pathogenic potential of oral streptococci. 2010, 5 (11):e13826 PLoS ONEen
dc.identifier.issn1932-6203
dc.identifier.pmid21072208
dc.identifier.doi10.1371/journal.pone.0013826
dc.identifier.urihttp://hdl.handle.net/10033/117165
dc.description.abstractOral streptococci are a heterogeneous group of human commensals, with a potential to cause serious infections. Activation of plasminogen has been shown to increase the virulence of typical human pathogenic streptococci such as S. pneumoniae. One important factor for plasminogen activation is the streptococcal α-enolase. Here we report that plasminogen activation is also common in oral streptococci species involved in clinical infection and that it depends on the action of human plasminogen activators. The ability to activate plasminogen did not require full conservation of the internal plasminogen binding sequence motif FYDKERKVY of α-enolase that was previously described as crucial for increased plasminogen binding, activation and virulence. Instead, experiments with recombinant α-enolase variants indicate that the naturally occurring variations do not impair plasminogen binding. In spite of these variations in the internal plasminogen binding motif oral streptococci showed similar activation of plasminogen. We conclude that the pathomechanism of plasminogen activation is conserved in oral streptococci that cause infections in human. This may contribute to their opportunistic pathogenic character that is unfurled in certain niches.
dc.language.isoenen
dc.titleContribution of plasminogen activation towards the pathogenic potential of oral streptococci.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.en
dc.identifier.journalPloS oneen
refterms.dateFOA2018-06-12T21:26:37Z
html.description.abstractOral streptococci are a heterogeneous group of human commensals, with a potential to cause serious infections. Activation of plasminogen has been shown to increase the virulence of typical human pathogenic streptococci such as S. pneumoniae. One important factor for plasminogen activation is the streptococcal α-enolase. Here we report that plasminogen activation is also common in oral streptococci species involved in clinical infection and that it depends on the action of human plasminogen activators. The ability to activate plasminogen did not require full conservation of the internal plasminogen binding sequence motif FYDKERKVY of α-enolase that was previously described as crucial for increased plasminogen binding, activation and virulence. Instead, experiments with recombinant α-enolase variants indicate that the naturally occurring variations do not impair plasminogen binding. In spite of these variations in the internal plasminogen binding motif oral streptococci showed similar activation of plasminogen. We conclude that the pathomechanism of plasminogen activation is conserved in oral streptococci that cause infections in human. This may contribute to their opportunistic pathogenic character that is unfurled in certain niches.


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