Bioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid.
Name:
Homann et al_final.pdf
Size:
785.5Kb
Format:
PDF
Description:
Open Access publication
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Issue Date
2010
Metadata
Show full item recordAbstract
Sialic acids are located at the termini of mammalian cell-surface glycostructures, which participate in essential interaction processes including adhesion of pathogens prior to infection and immunogenicity. Here we present the synthesis and bioorthogonal metabolic incorporation of the sialic acid analogue N-(1-oxohex-5-ynyl)neuraminic acid (Neu5Hex) into the cell-surface glycocalyx of a human larynx carcinoma cell line (HEp-2) and its fluorescence labelling by click chemistry.Citation
Bioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid. 2010, 6:24 Beilstein J Org ChemAffiliation
University of Würzburg, Department of Organic Chemistry, Am Hubland, 97074 Würzburg, Germany.PubMed ID
20502611Type
ArticleLanguage
enISSN
1860-5397ae974a485f413a2113503eed53cd6c53
10.3762/bjoc.6.24
Scopus Count
The following license files are associated with this item:
Related articles
- Metabolic Glycoengineering Enables the Ultrastructural Visualization of Sialic Acids in the Glycocalyx of the Alveolar Epithelial Cell Line hAELVi.
- Authors: Brandt R, Timm S, Gorenflos López JL, Kwame Abledu J, Kuebler WM, Hackenberger CPR, Ochs M, Lopez-Rodriguez E
- Issue date: 2020
- SiaNAl can be efficiently incorporated in glycoproteins of human mesenchymal stromal cells by metabolic glycoengineering.
- Authors: Mut J, Altmann S, Reising S, Meißner-Weigl J, Driessen MD, Ebert R, Seibel J
- Issue date: 2024 Jan 8
- Molecular imaging based on metabolic glycoengineering and bioorthogonal click chemistry.
- Authors: Yoon HY, Koo H, Kim K, Kwon IC
- Issue date: 2017 Jul
- In vivo stem cell tracking with imageable nanoparticles that bind bioorthogonal chemical receptors on the stem cell surface.
- Authors: Lee S, Yoon HI, Na JH, Jeon S, Lim S, Koo H, Han SS, Kang SW, Park SJ, Moon SH, Park JH, Cho YW, Kim BS, Kim SK, Lee T, Kim D, Lee S, Pomper MG, Kwon IC, Kim K
- Issue date: 2017 Sep
- Sialidases as regulators of bioengineered cellular surfaces.
- Authors: Zamora CY, Ryan MJ, d'Alarcao M, Kumar K
- Issue date: 2015 Jul