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dc.contributor.authorHomann, Arne
dc.contributor.authorQamar, Riaz-Ul
dc.contributor.authorSerim, Sevnur
dc.contributor.authorDersch, Petra
dc.contributor.authorSeibel, Jürgen
dc.date.accessioned2011-01-05T14:01:40Z
dc.date.available2011-01-05T14:01:40Z
dc.date.issued2010
dc.identifier.citationBioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid. 2010, 6:24 Beilstein J Org Chemen
dc.identifier.issn1860-5397
dc.identifier.pmid20502611
dc.identifier.doi10.3762/bjoc.6.24
dc.identifier.urihttp://hdl.handle.net/10033/118667
dc.description.abstractSialic acids are located at the termini of mammalian cell-surface glycostructures, which participate in essential interaction processes including adhesion of pathogens prior to infection and immunogenicity. Here we present the synthesis and bioorthogonal metabolic incorporation of the sialic acid analogue N-(1-oxohex-5-ynyl)neuraminic acid (Neu5Hex) into the cell-surface glycocalyx of a human larynx carcinoma cell line (HEp-2) and its fluorescence labelling by click chemistry.
dc.language.isoenen
dc.titleBioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid.en
dc.typeArticleen
dc.contributor.departmentUniversity of Würzburg, Department of Organic Chemistry, Am Hubland, 97074 Würzburg, Germany.en
dc.identifier.journalBeilstein journal of organic chemistryen
refterms.dateFOA2018-06-13T00:01:16Z
html.description.abstractSialic acids are located at the termini of mammalian cell-surface glycostructures, which participate in essential interaction processes including adhesion of pathogens prior to infection and immunogenicity. Here we present the synthesis and bioorthogonal metabolic incorporation of the sialic acid analogue N-(1-oxohex-5-ynyl)neuraminic acid (Neu5Hex) into the cell-surface glycocalyx of a human larynx carcinoma cell line (HEp-2) and its fluorescence labelling by click chemistry.


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