The vinculin-DeltaIn20/21 mouse: characteristics of a constitutive, actin-binding deficient splice variant of vinculin.
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Authors
Marg, SusannaWinkler, Ulrike
Sestu, Marcello
Himmel, Mirko
Schönherr, Madeleine
Bär, Janina
Mann, Amrit
Moser, Markus
Mierke, Claudia T
Rottner, Klemens
Blessing, Manfred
Hirrlinger, Johannes
Ziegler, Wolfgang H
Issue Date
2010
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Show full item recordAbstract
The cytoskeletal adaptor protein vinculin plays a fundamental role in cell contact regulation and affects central aspects of cell motility, which are essential to both embryonal development and tissue homeostasis. Functional regulation of this evolutionarily conserved and ubiquitously expressed protein is dominated by a high-affinity, autoinhibitory head-to-tail interaction that spatially restricts ligand interactions to cell adhesion sites and, furthermore, limits the residency time of vinculin at these sites. To date, no mutants of the vinculin protein have been characterized in animal models.Citation
The vinculin-DeltaIn20/21 mouse: characteristics of a constitutive, actin-binding deficient splice variant of vinculin. 2010, 5 (7):e11530 PLoS ONEAffiliation
Faculty of Medicine, Interdisciplinary Centre for Clinical Research (IZKF) Leipzig, University of Leipzig, Leipzig, Germany.Journal
PloS onePubMed ID
20644727Type
ArticleLanguage
enISSN
1932-6203ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0011530
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