Identification of oxylipins with antifungal activity by LC-MS/MS from the supernatant of Pseudomonas 42A2.

Martin-Arjol, I; Bassas-Galia, M; Bermudo, E; Garcia, F; Manresa, A

dc.contributor.author	Martin-Arjol, I
dc.contributor.author	Bassas-Galia, M
dc.contributor.author	Bermudo, E
dc.contributor.author	Garcia, F
dc.contributor.author	Manresa, A
dc.date.accessioned	2011-02-15T10:08:09Z
dc.date.available	2011-02-15T10:08:09Z
dc.date.issued	2010-05
dc.identifier.citation	Identification of oxylipins with antifungal activity by LC-MS/MS from the supernatant of Pseudomonas 42A2. 2010, 163 (4-5):341-6 Chem. Phys. Lipids	en
dc.identifier.issn	1873-2941
dc.identifier.pmid	20188718
dc.identifier.doi	10.1016/j.chemphyslip.2010.02.003
dc.identifier.uri	http://hdl.handle.net/10033/121916
dc.description.abstract	In microorganisms hydroxy fatty acids are produced from the biotransformation of unsaturated fatty acids. Such compounds belong to a class of oxylipins which are reported to perform a variety of biological functions such as anti-inflammatory or cytotoxic activity. These compounds have been found in rice and timothy plants after being infected by specific fungus. When grown in submerged culture with linoleic acid, Pseudomonas 42A2 accumulated in the supernatant several hydroxy fatty acids. In this work LC-MS/MS has been used to elucidate the structure of the components form the organic extract: 9-hydroxy-10,12-octadecadienoic acid; 13-hydroxy-9,11-octadecadienoic acid; 7,10-dihydroxy-8E-octadecenoic acid; 9,10,13-trihydroxy-11-octadecenoic acid and 9,12,13-trihydroxy-10-octadecenoic acid. Antimicrobial activity against several pathogenic fungal strains is presented: MIC (microg/mL) Verticillium dhaliae, 32; Macrophonia phaesolina, 32; Arthroderma uncinatum, 32; Trycophyton mentagrophytes, 64.
dc.language.iso	en	en
dc.subject.mesh	Antifungal Agents	en
dc.subject.mesh	Cell Survival	en
dc.subject.mesh	Cell-Free System	en
dc.subject.mesh	Chromatography, Liquid	en
dc.subject.mesh	Fungi	en
dc.subject.mesh	Mass Spectrometry	en
dc.subject.mesh	Oxylipins	en
dc.subject.mesh	Pseudomonas	en
dc.title	Identification of oxylipins with antifungal activity by LC-MS/MS from the supernatant of Pseudomonas 42A2.	en
dc.type	Article	en
dc.contributor.department	Laboratori de Microbiologia, Facultat de Farmàcia, Universitat de Barcelona, Joan XXIII s/n, Barcelona, Spain.	en
dc.identifier.journal	Chemistry and physics of lipids	en
refterms.dateFOA	2018-05-23T12:10:33Z
html.description.abstract	In microorganisms hydroxy fatty acids are produced from the biotransformation of unsaturated fatty acids. Such compounds belong to a class of oxylipins which are reported to perform a variety of biological functions such as anti-inflammatory or cytotoxic activity. These compounds have been found in rice and timothy plants after being infected by specific fungus. When grown in submerged culture with linoleic acid, Pseudomonas 42A2 accumulated in the supernatant several hydroxy fatty acids. In this work LC-MS/MS has been used to elucidate the structure of the components form the organic extract: 9-hydroxy-10,12-octadecadienoic acid; 13-hydroxy-9,11-octadecadienoic acid; 7,10-dihydroxy-8E-octadecenoic acid; 9,10,13-trihydroxy-11-octadecenoic acid and 9,12,13-trihydroxy-10-octadecenoic acid. Antimicrobial activity against several pathogenic fungal strains is presented: MIC (microg/mL) Verticillium dhaliae, 32; Macrophonia phaesolina, 32; Arthroderma uncinatum, 32; Trycophyton mentagrophytes, 64.