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    Control of smooth muscle cell proliferation by ferrous iron.

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    Authors
    Mueller, Peter P
    May, Tobias
    Perz, Angela
    Hauser, Hansjörg
    Peuster, Matthias
    Issue Date
    2006-04-01
    
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    Abstract
    This study was conducted to determine the interaction of individual corrosion products from biodegradable iron stents with cells from the adjacent tissue. The response of human umbilical venous smooth muscle cells (SMCs) to an excess of ferrous ions was investigated in a cell culture model at the phenotypic and at the molecular level. When soluble ferrous ions were added to the cell culture medium the cell growth rate was reduced. Gene expression profiling indicated a reduction in the amounts of mRNA from genes that are required for cell proliferation. In addition, mRNA was regulated from multiple genes involved in iron homeostasis, DNA replication and lipid metabolism. In conclusion, ions released from iron stents could reduce the vascular SMC proliferation rate by influencing growth-related gene expression and may therefore play a beneficial role in antagonizing restenosis in vivo.
    Citation
    Biomaterials 2006, 27(10):2193-200
    URI
    http://hdl.handle.net/10033/12367
    DOI
    10.1016/j.biomaterials.2005.10.042
    PubMed ID
    16310850
    Type
    Article
    Language
    en
    ISSN
    0142-9612
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.biomaterials.2005.10.042
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