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    Evaluation of the E test for the assessment of synergy of antibiotic combinations against multiresistant Pseudomonas aeruginosa isolates from cystic fibrosis patients.

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    Authors
    Balke, B
    Hogardt, M
    Schmoldt, S
    Hoy, L
    Weissbrodt, H
    Häussler, S
    Issue Date
    2006-01-01
    
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    Abstract
    The determination of synergistic effects of antimicrobial drug combinations can lead to improved therapeutic options in the antibiotic treatment of cystic fibrosis patients who are chronically infected with multiresistant Pseudomonas aeruginosa isolates. The aim of this study was to evaluate the performance of the E test versus the standard agar dilution checkerboard susceptibility test in the assessment of synergy and, in addition, to determine the activity of two antimicrobial combinations against 163 multiresistant P. aeruginosa isolates from cystic fibrosis patients. The agreement between the checkerboard method and the E test was excellent (>90%) for nonmucoid as well as mucoid isolates from cystic fibrosis patients. The rate of synergy was higher for the antibiotic combination of ceftazidime and tobramycin (28.8% of the cystic fibrosis strains) than for the combination of meropenem and tobramycin (19.0%). However, the probability of synergy for the second antibiotic combination increased significantly when the synergy of the first antibiotic combination had already been demonstrated (Fischer's exact test, p=0.049). The results show that the E test is a valuable and practical method for routine microbiological diagnostics and can aid in the selection of improved antibiotic options in the treatment of cystic fibrosis patients chronically infected with P. aeruginosa.
    Citation
    Eur. J. Clin. Microbiol. Infect. Dis. 2006, 25(1):25-30
    URI
    http://hdl.handle.net/10033/12855
    DOI
    10.1007/s10096-005-0076-9
    PubMed ID
    16402226
    Type
    Article
    Language
    en
    ISSN
    0934-9723
    ae974a485f413a2113503eed53cd6c53
    10.1007/s10096-005-0076-9
    Scopus Count
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    Publications of Dept. Cell Biology (ZB)

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