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    Adult murine hematopoiesis can proceed without beta1 and beta7 integrins.

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    Authors
    Bungartz, Gerd
    Stiller, Sebastian
    Bauer, Martina
    Müller, Werner
    Schippers, Angela
    Wagner, Norbert
    Fässler, Reinhard
    Brakebusch, Cord
    Issue Date
    2006-09-15
    
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    Abstract
    The function of alpha4beta1 and alpha4beta7 integrins in hematopoiesis is controversial. While some experimental evidence suggests a crucial role for these integrins in retention and expansion of progenitor cells and lymphopoiesis, others report a less important role in hematopoiesis. Using mice with a deletion of the beta1 and the beta7 integrin genes restricted to the hematopoietic system we show here that alpha4beta1 and alpha4beta7 integrins are not essential for differentiation of lymphocytes or myelocytes. However, beta1beta7 mutant mice displayed a transient increase of colony-forming unit (CFU-C) progenitors in the bone marrow and, after phenylhydrazine-induced anemia, a decreased number of splenic erythroid colony-forming units in culture (CFUe's). Array gene expression analysis of CD4(+)CD8(+) double-positive (DP) and CD4(-)CD8(-) double-negative (DN) thymocytes and CD19(+) and CD4(+) splenocytes did not provide any evidence for a compensatory mechanism explaining the mild phenotype. These data show that alpha4beta1 and alpha4beta7 are not required for blood cell differentiation, although in their absence alterations in numbers and distribution of progenitor cells were observed.
    Citation
    Blood 2006, 108(6):1857-64
    URI
    http://hdl.handle.net/10033/14518
    DOI
    10.1182/blood-2005-10-007658
    PubMed ID
    16735603
    Type
    Article
    Language
    en
    ISSN
    0006-4971
    ae974a485f413a2113503eed53cd6c53
    10.1182/blood-2005-10-007658
    Scopus Count
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