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    The Pseudomonas aeruginosa quinolone signal (PQS) has an iron-chelating activity.

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    Authors
    Bredenbruch, Florian
    Geffers, Robert cc
    Nimtz, Manfred
    Buer, Jan
    Häussler, Susanne
    Issue Date
    2006-08-01
    
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    Abstract
    Virulence factor production and the development of biofilms in Pseudomonas aeruginosa have been shown to be regulated by two hierarchically organized quorum-sensing systems activated by two types of small acyl-homoserine lactone signal molecules. Recently, a third type of bacterial signal molecule, the Pseudomonas quinolone signal (PQS), has been identified, which positively regulates a subset of genes dependent on the quorum-sensing systems. However, the molecular mechanism underlying PQS signalling has remained poorly understood. In this study the global transcriptional profile of P. aeruginosa in response to PQS revealed a marked upregulation of genes belonging to the tightly interdependent functional groups of the iron acquisition and the oxidative stress response. Remarkably, most of the differentially regulated genes, as well as the induction of rhlR, could be traced back to an iron-chelating effect of PQS. Our results amount to the elucidation of how PQS affects P. aeruginosa and have important implications for the understanding of the complex regulatory circuits involved in P. aeruginosa gene regulation.
    Citation
    Environ. Microbiol. 2006, 8(8):1318-29
    URI
    http://hdl.handle.net/10033/14549
    DOI
    10.1111/j.1462-2920.2006.01025.x
    PubMed ID
    16872396
    Type
    Article
    Language
    en
    ISSN
    1462-2912
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1462-2920.2006.01025.x
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