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    Intranasal IFNgamma extends passive IgA antibody protection of mice against Mycobacterium tuberculosis lung infection.

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    Authors
    Reljic, R
    Clark, S O
    Williams, A
    Falero-Diaz, G
    Singh, M
    Challacombe, S
    Marsh, P D
    Ivanyi, J
    Issue Date
    2006-03-01
    
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    Abstract
    Intranasal inoculation of mice with monoclonal IgA against the alpha-crystallin (acr1) antigen can diminish the tuberculous infection in the lungs. As this effect has been observed only over a short-term, we investigated if it could be extended by inoculation of IFNgamma 3 days before infection, and further co-inoculations with IgA, at 2 h before and 2 and 7 days after aerosol infection with Mycobacterium tuberculosis H37Rv. This treatment reduced the lung infection at 4 weeks more than either IgA or IFNgamma alone (i.e. 17-fold, from 4.2 x 10(7) to 2.5 x 10(6) CFU, P = 0.006), accompanied also by lower granulomatous infiltration of the lungs. IFNgamma added prior to infection of mouse peritoneal macrophages with IgA-opsonized bacilli resulted in a synergistic increase of nitric oxide and TNFalpha production and a 2-3 fold decrease in bacterial counts. Our improved results suggest, that combined treatment with IFNgamma and IgA could be developed towards prophylactic treatment of AIDS patients, or as an adjunct to chemotherapy.
    Citation
    Clin. Exp. Immunol. 2006, 143(3):467-73
    URI
    http://hdl.handle.net/10033/14575
    DOI
    10.1111/j.1365-2249.2006.03012.x
    PubMed ID
    16487246
    Type
    Article
    Language
    en
    ISSN
    0009-9104
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2249.2006.03012.x
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    publications of the research group genomeanalytics (GMAK)

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