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    The making of filopodia.

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    Authors
    Faix, Jan
    Rottner, Klemens
    Issue Date
    2006-02-01
    
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    Abstract
    Filopodia are rod-like cell surface projections filled with bundles of parallel actin filaments. They are found on a variety of cell types and have been ascribed sensory or exploratory functions. Filopodium formation is frequently associated with protrusion of sheet-like actin filament arrays called lamellipodia and membrane ruffles, but, in comparison to these structures, the molecular details underpinning the initiation and maintenance of filopodia are only just beginning to emerge. Recent advances have improved our understanding of the molecular requirements for filopodium protrusion and have yielded insights into the inter-relationships between lamellipodia and filopodia, the two 'sub-compartments' of the protrusive actin cytoskeleton.
    Citation
    Curr. Opin. Cell Biol. 2006, 18(1):18-25
    URI
    http://hdl.handle.net/10033/14602
    DOI
    10.1016/j.ceb.2005.11.002
    PubMed ID
    16337369
    Type
    Article
    Language
    en
    ISSN
    0955-0674
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ceb.2005.11.002
    Scopus Count
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    Publications of RG Cytoskeleton Dynamics (CYD)

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