Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractInterleukin-10 (IL-10) is an important regulator of immune responses secreted by different cell types. We have previously shown that mice with selective inactivation of the IL-10 gene in T cells suffer from deregulated T cell responses similar to those observed in IL-10(-/-) animals. Unlike IL-10(-/-) mice, however, T cell-specific mutants do not mount an enhanced innate immune response to LPS, which must, therefore, be subject to control by IL-10 from non-T cells. Herein we show that subcutaneous injection of LPS, which causes moderate local inflammation in WT and T cell-specific IL-10 mutant mice, results in augmented inflammatory infiltration and extensive tissue necrosis in mice with deficiency for IL-10 in macrophages and neutrophils. Correspondingly, we observed an enhanced sensitivity of the macrophage/neutrophil-specific IL-10 mutants to systemic LPS exposure when compared with WT animals. In contrast, the inflammatory response of these mutants to CpG oligodeoxynucleotides was not different from that of WT mice. While IL-10(-/-) mice developed massive inflammation, necrosis and increased serum cytokine levels after subcutaneous CpG injection, only moderate responses were observed in macrophage/neutrophil-specific IL-10 mutant and WT mice. These results show that different innate immune responses can be subject to control by IL-10 from different cellular sources.
CitationEur. J. Immunol. 2006, 36(12):3248-55
- Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model.
- Authors: Pils MC, Pisano F, Fasnacht N, Heinrich JM, Groebe L, Schippers A, Rozell B, Jack RS, Müller W
- Issue date: 2010 Feb
- Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize lipopolysaccharide-induced inflammation in the lower respiratory tract through an IL-12-dependent pathway.
- Authors: Schwartz DA, Wohlford-Lenane CL, Quinn TJ, Krieg AM
- Issue date: 1999 Jul 1
- CpG-containing oligodeoxynucleotides induce TNF-alpha and IL-6 production but not degranulation from murine bone marrow-derived mast cells.
- Authors: Zhu FG, Marshall JS
- Issue date: 2001 Feb
- Role of endothelial TLR4 for neutrophil recruitment into central nervous system microvessels in systemic inflammation.
- Authors: Zhou H, Andonegui G, Wong CH, Kubes P
- Issue date: 2009 Oct 15
- Selective down-regulation of neutrophil Mac-1 in endotoxemic hepatic microcirculation via IL-10.
- Authors: Menezes GB, Lee WY, Zhou H, Waterhouse CC, Cara DC, Kubes P
- Issue date: 2009 Dec 1