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    ISPa20 advances the individual evolution of Pseudomonas aeruginosa clone C subclone C13 strains isolated from cystic fibrosis patients by insertional mutagenesis and genomic rearrangements.

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    Authors
    Kresse, Andreas U
    Blöcker, Helmut
    Römling, Ute
    Issue Date
    2006-05
    
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    Abstract
    Pseudomonas aeruginosa clone C strains, which chronically colonize the lungs of cystic fibrosis patients reorganize their genome structure. In this study, a novel member of the IS3 subfamily of IS elements, ISPa20, was detected which was specific for clone C subclone C13 strains. ISPa20, which was present in high copy number, mediated events of genomic reorganization. ISPa20 was inserted into P. aeruginosa backbone genes leading to adaptation to the cystic fibrosis lung habitat and into DNA acquired through horizontal gene transfer. Further on, large chromosomal inversions were mediated by ISPa20. In contrast to strains of other subclonal linages high rates of genomic rearrangements of subclone C13 strains were observed in vitro. The acquisition of mobile elements by P. aeruginosa clone C strains in the lungs of cystic fibrosis patients supports the chronic colonization by insertional mutagenesis and chromosome restructuring leading to microevolution within clone C that reflects macroevolution observed on the species level.
    Citation
    ISPa20 advances the individual evolution of Pseudomonas aeruginosa clone C subclone C13 strains isolated from cystic fibrosis patients by insertional mutagenesis and genomic rearrangements. 2006, 185 (4):245-54 Arch. Microbiol.
    Affiliation
    Research Group Clonal Variability, Division of Cell- and Immune Biology, GBF - German Research Centre for Biotechnology, Mascheroder Weg 1, 38124, Braunschweig, Germany.
    Journal
    Archives of microbiology
    URI
    http://hdl.handle.net/10033/15013
    DOI
    10.1007/s00203-006-0089-5
    PubMed ID
    16474952
    Type
    Article
    Language
    en
    ISSN
    0302-8933
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00203-006-0089-5
    Scopus Count
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    Publications of Dept. Cell Biology (ZB)

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