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    Vaccines against typhoid fever.

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    Guzman et al_final.pdf
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    Authors
    Guzman, Carlos A
    Borsutzky, Stefan
    Griot-Wenk, Monika
    Metcalfe, Ian C
    Pearman, Jon
    Collioud, Andre
    Favre, Didier
    Dietrich, Guido
    Issue Date
    2006-05-01
    
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    Abstract
    Because of high infectivity and significant disease burden, typhoid fever constitutes a major global health problem. Implementation of adequate food handling practices and establishment of safe water supplies are the cornerstone for the development of an effective prevention program. However, vaccination against typhoid fever remains an essential tool for the effective management of this disease. Currently, there are two well tolerated and effective licensed vaccines. One is based on defined subunit virulence (Vi) polysaccharide antigen and can be administered either intramuscularly or subcutaneously and the other is based on the use of live attenuated bacteria for oral administration. The advantages and disadvantages of the various approaches taken in the development of a vaccine against typhoid fever are discussed, along with the potential for future vaccine candidates.
    Citation
    Vaccines against typhoid fever. 2006, 24 (18):3804-11 Vaccine
    Affiliation
    Vaccine Research Group, Division of Microbiology, GBF-German Research Centre for Biotechnology, Mascheroder Weg 1, Braunschweig, Germany.
    Journal
    Vaccine
    URI
    http://hdl.handle.net/10033/15855
    DOI
    10.1016/j.vaccine.2005.07.111
    PubMed ID
    16278037
    Type
    Article
    Language
    en
    ISSN
    0264-410X
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.vaccine.2005.07.111
    Scopus Count
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    publications of the research group vaccinology and applied microbiology (VAC)

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