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    Elevated expression of VEGFR-3 in lymphatic endothelial cells from lymphangiomas.

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    Authors
    Norgall, Susanne
    Papoutsi, Maria
    Rössler, Jochen
    Schweigerer, Lothar
    Wilting, Jörg
    Weich, Herbert A
    Issue Date
    2007
    
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    Abstract
    BACKGROUND: Lymphangiomas are neoplasias of childhood. Their etiology is unknown and a causal therapy does not exist. The recent discovery of highly specific markers for lymphatic endothelial cells (LECs) has permitted their isolation and characterization, but expression levels and stability of molecular markers on LECs from healthy and lymphangioma tissues have not been studied yet. We addressed this problem by profiling LECs from normal dermis and two children suffering from lymphangioma, and also compared them with blood endothelial cells (BECs) from umbilical vein, aorta and myometrial microvessels. METHODS: Lymphangioma tissue samples were obtained from two young patients suffering from lymphangioma in the axillary and upper arm region. Initially isolated with anti-CD31 (PECAM-1) antibodies, the cells were separated by FACS sorting and magnetic beads using anti-podoplanin and/or LYVE-1 antibodies. Characterization was performed by FACS analysis, immunofluorescence staining, ELISA and micro-array gene analysis. RESULTS: LECs from foreskin and lymphangioma had an almost identical pattern of lymphendothelial markers such as podoplanin, Prox1, reelin, cMaf and integrin-alpha1 and -alpha9. However, LYVE-1 was down-regulated and VEGFR-2 and R-3 were up-regulated in lymphangiomas. Prox1 was constantly expressed in LECs but not in any of the BECs. CONCLUSION: LECs from different sources express slightly variable molecular markers, but can always be distinguished from BECs by their Prox1 expression. High levels of VEGFR-3 and -2 seem to contribute to the etiology of lymphangiomas.
    Citation
    Elevated expression of VEGFR-3 in lymphatic endothelial cells from lymphangiomas. 2007, 7:105 BMC Cancer
    Affiliation
    Department Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig, Germany. susannenorgall@gmx.de <susannenorgall@gmx.de>
    Journal
    BMC cancer
    URI
    http://hdl.handle.net/10033/16274
    DOI
    10.1186/1471-2407-7-105
    PubMed ID
    17584927
    Type
    Article
    Language
    en
    ISSN
    1471-2407
    ae974a485f413a2113503eed53cd6c53
    10.1186/1471-2407-7-105
    Scopus Count
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