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    Remote control of tumour-targeted Salmonella enterica serovar Typhimurium by the use of L-arabinose as inducer of bacterial gene expression in vivo.

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    Authors
    Loessner, Holger
    Endmann, Anne
    Leschner, Sara
    Westphal, Kathrin
    Rohde, Manfred
    Miloud, Tewfik
    Hämmerling, Günter
    Neuhaus, Klaus
    Weiss, Siegfried
    Issue Date
    2007-06
    
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    Abstract
    We have used Salmonella enterica serovar Typhimurium (S. typhimurium) which are able to colonize tumours besides spleen and liver. Bacteria were equipped with constructs encoding green fluorescent protein or luciferase as reporters under control of the promoter PBAD that is inducible with L-arabinose. Reporter genes could be induced in culture but also when the bacteria resided within the mouse macrophages J774A.1. More important, strong expression of reporters by the bacteria could be detected in mice after administration of L-arabinose. This was especially pronounced in bacteria colonizing tumours. Histology demonstrated that the bacteria had accumulated in and close to necrotic areas of tumours. Bacterial gene induction was observed in both regions. PBAD is tightly controlled also in vivo because gene E of bacteriophage PhiX174 could be introduced as inducible suicide gene. The possibility to deliberately induce genes in bacterial carriers within the host should render them extremely powerful tools for tumour therapy.
    Citation
    Remote control of tumour-targeted Salmonella enterica serovar Typhimurium by the use of L-arabinose as inducer of bacterial gene expression in vivo. 2007, 9 (6):1529-37 Cell. Microbiol.
    Affiliation
    Molecular Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany. holger.loessner@helmholtz-hzi.de
    Journal
    Cellular microbiology
    URI
    http://hdl.handle.net/10033/16615
    DOI
    10.1111/j.1462-5822.2007.00890.x
    PubMed ID
    17298393
    Type
    Article
    Language
    en
    ISSN
    1462-5814
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1462-5822.2007.00890.x
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