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    Intranasal vaccination with recombinant outer membrane protein CD and adamantylamide dipeptide as the mucosal adjuvant enhances pulmonary clearance of Moraxella catarrhalis in an experimental murine model.

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    Authors
    Becker, Pablo D
    Bertot, Gustavo M
    Souss, David
    Ebensen, Thomas
    Guzmán, Carlos A
    Grinstein, Saúl
    Issue Date
    2007-04
    
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    Abstract
    Moraxella catarrhalis causes acute otitis media in children and lower respiratory tract infections in adults and elderly. In children the presence of antibodies against the highly conserved outer membrane protein CD correlates with protection against infection, suggesting that this protein may be useful as a vaccine antigen. However, native CD is difficult to purify, and it is still unclear if recombinant CD (rCD) is a valid alternative. We performed a side-by-side comparison of the immunogenicities and efficacies of vaccine formulations containing native CD and rCD with adamantylamide dipeptide as the mucosal adjuvant. Intranasal vaccination of mice stimulated the production of high CD-specific antibody titers in sera and of secretory immunoglobulin A in mucosal lavages, which cross-recognized both antigens. While vaccination with native CD increased the number of interleukin-2 (IL-2)- and gamma interferon-producing cells, rCD mainly stimulated IL-4-secreting cells. Nevertheless, efficient bacterial clearance was observed in the lungs of challenged mice receiving native CD and in the lungs of challenged mice receiving rCD (96% and 99%, respectively). Thus, rCD is a promising candidate for incorporation in vaccine formulations for use against M. catarrhalis.
    Citation
    Intranasal vaccination with recombinant outer membrane protein CD and adamantylamide dipeptide as the mucosal adjuvant enhances pulmonary clearance of Moraxella catarrhalis in an experimental murine model. 2007, 75 (4):1778-84 Infect. Immun.
    Affiliation
    Virology Laboratory, Ricardo Gutiérrez Children's Hospital, Gallo 1330, 1425 Buenos Aires, Argentina.
    Journal
    Infection and immunity
    URI
    http://hdl.handle.net/10033/17192
    DOI
    10.1128/IAI.01081-06
    PubMed ID
    17101651
    Type
    Article
    Language
    en
    ISSN
    0019-9567
    ae974a485f413a2113503eed53cd6c53
    10.1128/IAI.01081-06
    Scopus Count
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    publications of the research group vaccinology and applied microbiology (VAC)

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