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    Screening of photochemically grafted polymer films for compatibility with osteogenic precursor cells.

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    Authors
    Adden, Nina
    Hoffmann, Andrea
    Gross, Gerhard
    Windhagen, Henning
    Thorey, Fritz
    Menzel, Henning
    Issue Date
    2007
    
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    Abstract
    Surfaces of biomaterials often do not have the ideal properties for direct application in vivo. Although titanium and its alloys show a good biocompatibility, in some applications there is still need to improve the osteoblast adhesion to titanium implants. A polymeric surface coating is an ideal solution because the polymer can be adjusted to the needs of the application and can be bound to the surface by the photochemical grafting method. Therefore, 22 different polymers were tested for their compatibility using a murine mesenchymal progenitor cell line and three polymers were identified for which more elaborate investigations are reasonable. It was investigated whether or not the results of the cell culture test can be correlated with, e.g., the wetting properties. Indeed it was found that a contact angle above approx. 45 degrees was necessary for good cell adhesion and proliferation. However, otherwise no clear correlation between the contact angle hysteresis or the functionalities of the polymers and the cell growth was observed.
    Citation
    Screening of photochemically grafted polymer films for compatibility with osteogenic precursor cells. 2007, 18 (3):303-16notJ Biomater Sci Polym Ed
    Affiliation
    Institut für Technische Chemie, Abt. TC Makromolekularer Stoffe, Technische Universität Braunschweig, Hans-Sommer-Strasse 10, D-38106 Braunschweig, Germany.
    Journal
    Journal of biomaterials science. Polymer edition
    URI
    http://hdl.handle.net/10033/17232
    PubMed ID
    17471767
    Type
    Article
    Language
    en
    ISSN
    0920-5063
    Collections
    Publications of Dept. Gene Regulation and Differentiation (RDIF)

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