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Authors
Chmielowiec, JolantaBorowiak, Malgorzata
Morkel, Markus
Stradal, Theresia
Munz, Barbara
Werner, Sabine
Wehland, Jürgen
Birchmeier, Carmen
Birchmeier, Walter
Issue Date
2007-04-09
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Show full item recordAbstract
Wound healing of the skin is a crucial regenerative process in adult mammals. We examined wound healing in conditional mutant mice, in which the c-Met gene that encodes the receptor of hepatocyte growth factor/scatter factor was mutated in the epidermis by cre recombinase. c-Met-deficient keratinocytes were unable to contribute to the reepithelialization of skin wounds. In conditional c-Met mutant mice, wound closure was slightly attenuated, but occurred exclusively by a few (5%) keratinocytes that had escaped recombination. This demonstrates that the wound process selected and amplified residual cells that express a functional c-Met receptor. We also cultured primary keratinocytes from the skin of conditional c-Met mutant mice and examined them in scratch wound assays. Again, closure of scratch wounds occurred by the few remaining c-Met-positive cells. Our data show that c-Met signaling not only controls cell growth and migration during embryogenesis but is also essential for the generation of the hyperproliferative epithelium in skin wounds, and thus for a fundamental regenerative process in the adult.Citation
c-Met is essential for wound healing in the skin. 2007, 177 (1):151-62 J. Cell Biol.Affiliation
Department of Cancer Biology, Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany.Journal
The Journal of cell biologyPubMed ID
17403932Type
ArticleLanguage
enISSN
0021-9525ae974a485f413a2113503eed53cd6c53
10.1083/jcb.200701086
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