Genetic variation in group A streptococci.

McMillan, David J; Sriprakash, Kadaba S; Chhatwal, Gursharan S

dc.contributor.author	McMillan, David J
dc.contributor.author	Sriprakash, Kadaba S
dc.contributor.author	Chhatwal, Gursharan S
dc.date.accessioned	2008-03-03T14:20:49Z
dc.date.available	2008-03-03T14:20:49Z
dc.date.issued	2007-11
dc.identifier.citation	Genetic variation in group A streptococci. 2007, 297 (7-8):525-32 Int. J. Med. Microbiol.	en
dc.identifier.issn	1438-4221
dc.identifier.pmid	17459766
dc.identifier.doi	10.1016/j.ijmm.2007.02.007
dc.identifier.uri	http://hdl.handle.net/10033/19553
dc.description.abstract	Group A streptococcus (GAS) is responsible for a range of human diseases that vary in their clinical manifestations and severity. While numerous virulence factors have been described, the way these factors interact to promote different streptococcal diseases is less clear. In order to identify multifactorial relationships between GAS and the human host, novel high-throughput techniques such as microarrays are necessary. We have performed comparative studies using custom-designed virulence arrays to enhance our understanding of the high degree of genotypic variation that occurs in streptococci. This study has pointed to mobile genetic elements as the major agents that promote variation. Our results show that multiple combinations of genes might bring about similar clinical pictures. This adds further complexity to the intricate relationship between pathogen and host.
dc.language.iso	en	en
dc.subject.mesh	Genotype	en
dc.subject.mesh	Humans	en
dc.subject.mesh	Streptococcal Infections	en
dc.subject.mesh	Streptococcus	en
dc.subject.mesh	Streptococcus pyogenes	en
dc.subject.mesh	Variation (Genetics)	en
dc.title	Genetic variation in group A streptococci.	en
dc.type	Article	en
dc.contributor.department	Department of Microbial Pathogenesis, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, D-38124 Braunschweig, Germany.	en
dc.identifier.journal	International journal of medical microbiology : IJMM	en
refterms.dateFOA	2018-06-12T19:58:35Z
html.description.abstract	Group A streptococcus (GAS) is responsible for a range of human diseases that vary in their clinical manifestations and severity. While numerous virulence factors have been described, the way these factors interact to promote different streptococcal diseases is less clear. In order to identify multifactorial relationships between GAS and the human host, novel high-throughput techniques such as microarrays are necessary. We have performed comparative studies using custom-designed virulence arrays to enhance our understanding of the high degree of genotypic variation that occurs in streptococci. This study has pointed to mobile genetic elements as the major agents that promote variation. Our results show that multiple combinations of genes might bring about similar clinical pictures. This adds further complexity to the intricate relationship between pathogen and host.