Dynamics of reductive genome evolution in mitochondria and obligate intracellular microbes.
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AbstractReductive evolution in mitochondria and obligate intracellular microbes has led to a significant reduction in their genome size and guanine plus cytosine content (GC). We show that genome shrinkage during reductive evolution in prokaryotes follows an exponential decay pattern and provide a method to predict the extent of this decay on an evolutionary timescale. We validated predictions by comparison with estimated extents of genome reduction known to have occurred in mitochondria and Buchnera aphidicola, through comparative genomics and by drawing on available fossil evidences. The model shows how the mitochondrial ancestor would have quickly shed most of its genome, shortly after its incorporation into the protoeukaryotic cell and prior to codivergence subsequent to the split of eukaryotic lineages. It also predicts that the primary rickettsial parasitic event would have occurred between 180 and 425 million years ago (MYA), an event of relatively recent evolutionary origin considering the fact that Rickettsia and mitochondria evolved from a common alphaproteobacterial ancestor. This suggests that the symbiotic events of Rickettsia and mitochondria originated at different time points. Moreover, our model results predict that the ancestor of Wigglesworthia glossinidia brevipalpis, dated around the time of origin of its symbiotic association with the tsetse fly (50-100 MYA), was likely to have been an endosymbiont itself, thus supporting an earlier proposition that Wigglesworthia, which is currently a maternally inherited primary endosymbiont, evolved from a secondary endosymbiont.
CitationDynamics of reductive genome evolution in mitochondria and obligate intracellular microbes. 2007, 24 (2):449-56 Mol. Biol. Evol.
AffiliationDepartment of Environmental Microbiology, Helmholtz Center for Infection Research, Braunschweig, Germany.
JournalMolecular biology and evolution
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- Genome reduction of the aphid endosymbiont Buchnera aphidicola in a recent evolutionary time scale.
- Authors: Gómez-Valero L, Silva FJ, Christophe Simon J, Latorre A
- Issue date: 2007 Mar 1
- Molecular systematics of aphids and their primary endosymbionts.
- Authors: Martinez-Torres D, Buades C, Latorre A, Moya A
- Issue date: 2001 Sep
- [Evolution of mitochondria].
- Authors: Litoshenko AIa
- Issue date: 2002 Sep-Oct
- Genome evolution in bacterial endosymbionts of insects.
- Authors: Wernegreen JJ
- Issue date: 2002 Nov
- The evolutionary fate of nonfunctional DNA in the bacterial endosymbiont Buchnera aphidicola.
- Authors: Gómez-Valero L, Latorre A, Silva FJ
- Issue date: 2004 Nov